A Combination of CD28 (rs1980422) and IRF5 (rs10488631) Polymorphisms Is Associated with Seropositivity in Rheumatoid Arthritis: A Case Control Study.

Lucia VernerovaFrantisek SpoutilMiroslav VlcekKatarina KrskovaAdela PenesovaMilada MeskovaAndrea MarkoKatarina RaslovaBranislav VohnoutJozef RovenskyZdenko KillingerIvana JochmanovaIvica LazurovaGuenter SteinerJosef SmolenRichard Imrich

Published in: PloS one (2016)

The association among multiple risk variants related to T cell receptor signalling with seropositivity may play an important role in distinct clinical phenotypes of RA. Our study demonstrates that multiparametric analyses represent a powerful tool for investigation of mutual relationships of potential risk factors in complex diseases such as RA.

Keyphrases

rheumatoid arthritis
disease activity
risk factors
ankylosing spondylitis
interstitial lung disease
copy number
systemic sclerosis
gene expression
human health
risk assessment
idiopathic pulmonary fibrosis