Spirometric phenotypes from early childhood to young adulthood: a Chronic Airway Disease Early Stratification study.
Gang WangJenny HallbergDimitrios CharalampopoulosMaribel Casas SanahujaRobab Breyer-KohansalArnulf LanghammerRaquel GranellJudith E VonkAnnemiek MianNúria OlveraLisbeth Mølgaard LaustsenEva RönmarkAlicia AbellanAlvar AgustiSyed Hasan ArshadAnna BergströmH Marike BoezenMarie-Kathrin BreyerOtto BurghuberAnneli Clea BolundAdnan CustovicGraham DevereuxGavin C DonaldsonLiesbeth DuijtsAna EspluguesRosa FanerFerran BallesterJudith M Garcia-AymerichUlrike GehringSadia HaiderSylvia HartlHelena BackmanJohn W HollowayGerard H KoppelmannAitana LertxundiTurid Lingaas HolmenLesley LoweSara M Mensink-BoutClare S MurrayGraham RobertsLinnea HedmanVivi SchlünssenTorben SigsgaardAngela SimpsonJordi SunyerMaties TorrentStephen W TurnerMaarten Van den BergeRoel C H VermeulenSigrid Anna Aalberg VikjordJadwiga A WedzichaAnke H Maitland van der ZeeErik MelénPublished in: ERJ open research (2021)
Obstructive and restrictive phenotypes were found to be relatively prevalent during childhood, which supports the early origins concept. Several well-known respiratory risk factors were associated with the obstructive phenotype, whereas only low BMI was associated with the restrictive phenotype, suggesting different underlying pathobiology of these two phenotypes.