Effects of doxorubicin administration on bone strength and quality in sedentary and physically active Wistar rats.

Hélder Rui Martins FonsecaA CarvalhoJ EstevesV I EstevesD Moreira-GonçalvesJ A Duarte

Published in: Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA (2016)

DOX negatively affects bone geometry, trabecular microarchitecture, and femur mechanical properties in growing Wistar rats. Exercise further aggravates the detrimental effects of past DOX treatment on bone mechanical properties.

Keyphrases

bone mineral density
postmenopausal women
physical activity
body composition
soft tissue
bone loss
bone regeneration
high intensity
cancer therapy
combination therapy
smoking cessation
replacement therapy