High-Grade Serous Carcinoma at Risk-Reducing Salpingo-Oophorectomy in Asymptomatic Carriers of BRCA1/2 Pathogenic Variants: Prevalence and Clinical Factors.

Iris A S StrootJan BrouwerJoost BartHarry HollemaDenise J Stommel-JennerMarise M WagnerH Lena C van DoornJoanne A de HulluKatja N GaarenstroomMarc BeurdenLuc R C W van LonkhuijzenBrigitte F M SlangenRonald P Zweemer Encarna B Gómez-García Margreet G E M AusemsIngrid A BoereKlaartje van EngelenChristi J van Asperen Marjanka K Schmidt Marijke R Wevers Geertruida H de Bock Marian J E Mouritsnull null

Published in: Journal of clinical oncology : official journal of the American Society of Clinical Oncology (2023)

-PV carriers. Consistent with the fallopian tube hypothesis, we found most lesions in the fallopian tube. Our results highlight the importance of timely RRSO with total removal and assessment of the fallopian tubes and show the protective effects of long-term OCP.

Keyphrases

high grade
low grade
breast cancer risk
copy number
gene expression