Incidence of fatigue and low-dose corticosteroid use in prostate cancer patients receiving systemic treatment: a meta-analysis of randomized controlled trials.

Matteo FerroGiuseppe Di LorenzoOttavio de CobelliDario BruzzesePiero PignataroMarco BorghesiGennaro MusiMihai Dorin VartolomeiVincenzo CosimatoAlessandro SerinoVincenzo IeluzziDaniela TerraccianoRocco DamianoFrancesco CantielloFrancesco Alessandro MistrettaMatteo MutoGiuseppe LucarelliPietro De PlacidoCarlo Buonerba

Published in: World journal of urology (2018)

Our findings highlight the need for ad hoc-designed prospective clinical trials to investigate whether the benefits associated with low-dose, daily corticosteroids outweigh the risks associated with corticosteroid-related adverse events such as fatigue.

Keyphrases

low dose
prostate cancer
clinical trial
high dose
sleep quality
systematic review
radical prostatectomy
risk factors
depressive symptoms
climate change
phase ii
open label