NGS of brush cytology samples improves the detection of high-grade dysplasia and cholangiocarcinoma in patients with primary sclerosing cholangitis: A retrospective and prospective study.
Sonja BoydTaru MustamäkiSjöblom NelliArno J NordinAndrea TencaKalle JokelainenTommi RantaperoThomas LiuksialaLaura LahtinenTeijo KuopioSoili KytöläHeikki MäkisaloMartti A FärkkiläJohanna T ArolaPublished in: Hepatology communications (2024)
In summary, NGS of BC samples increased the sensitivity of detecting biliary neoplasia compared with traditional cytology. Performing NGS on BC samples may help diagnose HGD or early CCA, benefiting the timing of liver transplantation.