Inactivation of the gene encoding procalcitonin prevents antibody-mediated arthritis.
Tazio MaleitzkeTamara DietrichAlexander HildebrandtJérôme WeberJessika AppeltDenise JahnEllen OttoDario ZochollShan JiangAnke BaranowskyGeorg N DudaSerafeim TsitsilonisJohannes KellerPublished in: Inflammation research : official journal of the European Histamine Research Society ... [et al.] (2023)
The inactivation of Calca and thereby PCT provided full protection from joint inflammation and arthritic bone loss in mice exposed to CAIA. Together with our previous findings on the pathophysiological function of Calca-derived peptides, these data indicate an independent pro-inflammatory role of PCT in RA.
Keyphrases
- bone loss
- rheumatoid arthritis
- oxidative stress
- electronic health record
- copy number
- high fat diet induced
- big data
- genome wide
- disease activity
- interstitial lung disease
- amino acid
- mouse model
- type diabetes
- ankylosing spondylitis
- skeletal muscle
- insulin resistance
- deep learning
- transcription factor
- idiopathic pulmonary fibrosis
- genome wide analysis