Vancomycin concentrations during cardiopulmonary bypass in pediatric cardiac surgery: a prospective study.
Fiorenza FerrariSimona BenegniEleonora MarinariRoberta HaibergerCristiana GaristoAlessandra RizzaChiara GiorniMaria Giovanna QuattroneSilvia ArpiccoElisabetta MuntoniPaola MillaZaccaria RicciPublished in: Perfusion (2021)
An AUCintra/MIC ⩾400 target was not reached in one-quarter of children undergoing heart surgery. Vancomycin peaked before the start of surgery and neonates were those with the lowest troughs. Vancomycin concentrations are affected by CPB hemodilution and by patients' age and weight.
Keyphrases
- minimally invasive
- methicillin resistant staphylococcus aureus
- cardiac surgery
- end stage renal disease
- coronary artery bypass
- ejection fraction
- chronic kidney disease
- newly diagnosed
- heart failure
- young adults
- surgical site infection
- acute kidney injury
- physical activity
- peritoneal dialysis
- atrial fibrillation
- staphylococcus aureus
- weight gain
- acute coronary syndrome
- body weight
- childhood cancer