The longevity-associated BPIFB4 gene supports cardiac function and vascularization in aging cardiomyopathy.

Monica CattaneoAntonio P BeltramiAnita C ThomasGaia SpinettiValeria AlvinoElisa AvolioClaudia VenezianoIrene Giulia RolleSandro SpongaElena SangalliAnna MaciagFabrizio Dal PiazCarmine VecchioneAishah AleneziStephen PaiseyAnnibale A PucaPaolo Madeddu

Published in: Cardiovascular research (2023)

We report the success of the LAV-BPIFB4 gene/protein in improving homeostatic processes in the heart's aging. These findings open to using LAV-BPIFB4 to reverse the decline of heart performance in older people.

Keyphrases

heart failure
copy number
genome wide
genome wide identification
atrial fibrillation
amino acid
binding protein
small molecule
genome wide analysis
drosophila melanogaster
tissue engineering