Relationship of serum beta-synuclein with blood biomarkers and brain atrophy.

Patrick OecklSarah Anderl-StraubAdrian DanekJanine Diehl-SchmidKlaus FassbenderKlaus FliessbachSteffen HalbgebauerHans-Jürgen HuppertzHolger JahnJan KassubekJohannes KornhuberBernhard LandwehrmeyerMartin LauerJohannes PrudloAnja SchneiderMatthias L SchroeterPetra SteinackerAlexander E VolkMatias WagnerJuliane WinkelmannJens WiltfangAlbert C LudolphMarkus Ottonull null

Published in: Alzheimer's & dementia : the journal of the Alzheimer's Association (2022)

Blood beta-synuclein is increased in Alzheimer's disease (AD) but not in frontotemporal lobar degeneration (FTLD) syndromes. Blood beta-synuclein correlates with temporal brain atrophy in AD. Blood beta-synuclein correlates with cognitive impairment in AD. The pattern of blood beta-synuclein changes in the investigated diseases is different to phosphorylated tau 181 (p-tau181) and neurofilament light (NfL).

Keyphrases

cognitive impairment
cerebrospinal fluid
white matter
resting state
multiple sclerosis
mass spectrometry
cognitive decline
functional connectivity
brain injury
subarachnoid hemorrhage
mild cognitive impairment