Genomic characterization of methicillin-susceptible Staphylococcus aureus carriage in patients on home parenteral nutrition and their caregivers.

Michelle GompelmanIngrid J M van WeerdenburgGuus T J WezendonkJordy P M CoolenReinier P AkkermansChantal P RoversHeiman F L WertheimGeert J A Wanten

Published in: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America (2023)

In this prospective study, patients on home parenteral nutrition were twice as likely to be colonized with Staphylococcus aureus if their caregivers were also carriers. Among S. aureus-positive patients and their caregivers, molecular analysis showed 68% genetically related strains. Despite decolonization, genetically related strains reappeared in 70% of patients.

Keyphrases

staphylococcus aureus
end stage renal disease
newly diagnosed
ejection fraction
prognostic factors
healthcare
gene expression
patient reported outcomes
patient reported
copy number