Shared and Distinct Aspects of the Sepsis Transcriptomic Response to Fecal Peritonitis and Pneumonia.

Katie L BurnhamEmma E DavenportJayachandran RadhakrishnanPeter HumburgAnthony C GordonPaula HuttonEduardo Svoren-JabaleraChristopher GarrardAdrian V S HillCharles J HindsJulian C Knight

Published in: American journal of respiratory and critical care medicine (2017)

The majority of the sepsis transcriptomic response is independent of the source of infection and includes signatures reflecting immune response state and prognosis. A modest number of genes show evidence of specificity. Our findings highlight opportunities for patient stratification and precision medicine in sepsis.

Keyphrases

septic shock
acute kidney injury
intensive care unit
immune response
single cell
genome wide
rna seq
gene expression
toll like receptor
transcription factor
community acquired pneumonia
bioinformatics analysis
respiratory failure