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Pericytes modulate endothelial inflammatory response during bacterial infection.

Thaynara P CarvalhoFrank A O ToledoDiego F A BautistaMonique F SilvaJefferson B S OliveiraPâmela A LimaFabíola B CostaNoelly Q RibeiroJee-Yon LeeAlexander BirbrairTatiane A PaixãoReneé M TsolisRenato de Lima Santos
Published in: mBio (2024)
A previously unknown mechanism by which pericytes modulate inflammation was discovered. The absence of pericytes or blocking interaction between pericytes and endothelium through connexin 43 results in stronger inflammation, which shifts our understanding of pericyte biology, from a structural cell to a player in controlling inflammation.
Keyphrases
  • oxidative stress
  • inflammatory response
  • nitric oxide
  • single cell
  • blood brain barrier
  • cell therapy
  • lipopolysaccharide induced
  • mesenchymal stem cells
  • bone marrow