Bile Acid Metabolism Mediates Cholesterol Homeostasis and Promotes Tumorigenesis in Clear Cell Renal Cell Carcinoma.
Romain RiscalSarah M GardnerNathan J CoffeyMadeleine CarensClementina A MesarosJimmy P XuYizheng XueLeah DavisSara DemczyszynAustin VogtAdam S OliaJennifer M FinanJason GodfreyDavid C. SchultzIan A BlairBrian KeithRonen MarmorsteinNicolas SkuliM Celeste SimonPublished in: Cancer research (2024)
The bile acid biosynthetic enzyme HSD3B7 is essential for ccRCC cell survival and can be targeted to induce accumulation of cholesterol-derived oxysterols and apoptotic cell death.