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Essential oil of Gallesia integrifolia is active against mycobacteria.

Débora C MontaholiTamires L ValverdeEloísa Gibin SampironWanessa C BortoluciZilda C GazimKatiany R Caleffi-FerracioliRegiane Bl ScodroVera Ld SiqueiraRosilene F Cardoso
Published in: Future microbiology (2023)
Background: There is critical need for new therapeutic options for treatment of diseases caused by mycobacteria. Materials & methods: Gallesia integrifolia essential oils (EOs) and crude extracts (CEs) were tested for their anti- Mycobacterium tuberculosis and anti-nontuberculous mycobacteria activity. Results: Minimum inhibitory concentration (MIC) of EOs ranged from 15.63 to 62.5 μg/ml against M. tuberculosis and 62.5 to >250 μg/ml against nontuberculous mycobacteria. CEs showed low activity. All EO tested demonstrated synergism with antituberculosis drugs. The cytotoxicity of EOs and CEs, in different cell lines, showed selectivity index from 2.2 to 9.8 and >0.056 to 2.0, respectively. Conclusion: G. integrifolia EOs are a candidate for the development of new therapeutic options in the treatment of tuberculosis and other mycobacterial diseases.
Keyphrases
  • mycobacterium tuberculosis
  • pulmonary tuberculosis
  • essential oil
  • hiv aids
  • emergency department
  • combination therapy
  • adverse drug
  • drug induced