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Segmentation of the Globus Pallidus Internus Using Probabilistic Diffusion Tractography for Deep Brain Stimulation Targeting in Parkinson Disease.

Erik H MiddlebrooksIbrahim Sacit TunaSanjeet S GrewalLeonardo AlmeidaMichael G HeckmanElizabeth R LesserKelly D FooteMichael S OkunVanessa Milanese Holanda Zimpel
Published in: AJNR. American journal of neuroradiology (2018)
In this pilot study, we assessed a novel method of segmentation of the globus pallidus internus based on probabilistic tractography as a supplement to traditional targeting methods. Our results suggest that our method may be an independent predictor of deep brain stimulation outcome, and evaluation of a larger cohort or prospective study is warranted to validate these findings.
Keyphrases
  • deep brain stimulation
  • parkinson disease
  • obsessive compulsive disorder
  • deep learning
  • convolutional neural network
  • white matter
  • cancer therapy
  • machine learning
  • drug delivery
  • multiple sclerosis