Role of IL-6/STAT3 pathway in mediating the protective effect of agomelatine against methotrexate-induced lung/intestinal tissues damage in rats.

Maha Yehia KamelSabreen Mahmoud AhmedWalaa Yehia AbdelzaherNermeen N WelsonAsmaa Mohamed Abdel-Aziz

Published in: Immunopharmacology and immunotoxicology (2021)

By reducing oxidative stress, inflammatory processes, and modulating the IL-6/STAT3 pathway, Ago has potent ameliorative effects against MTX-induced lung/intestinal toxicities.

Keyphrases

oxidative stress
diabetic rats
high glucose
cell proliferation
gene expression
dna damage
drug induced
high dose
ischemia reperfusion injury
low dose
endothelial cells
endoplasmic reticulum stress
anti inflammatory