PGC-1α regulates autophagy to promote fibroblast activation and tissue fibrosis.
Yun ZhangLichong ShenHonglin ZhuKatja DreissigackerDiana DistlerXiang ZhouAndrea Hermina GyörfiChristina BergmannXianyi MengClara DeesThuong Trinh-MinhIngo LudolphRaymund HorchAndreas RammingLarissa Valor-MéndezJörg H W DistlerPublished in: Annals of the rheumatic diseases (2020)
PGC-1α is upregulated in SSc and promotes autophagy to foster TGFβ-induced fibroblast activation. Targeting of PGC-1α prevents aberrant autophagy, inhibits fibroblast activation and tissue fibrosis and may over therapeutic potential.