Increased water intake dilutes protective uromodulin levels in urine and results in increased rates of pyelonephritis in a murine model.
Aimi D K HamiltonLaura V SparsoeMathias SkovNanna JohnsenMette H ChreistensenThomas Juhl CorydonHelle A PraetoriusPublished in: Acta physiologica (Oxford, England) (2024)
Increased water intake and urine flow in mice will markedly increase the risk of pyelonephritis. The increased risk may reflect reduced urine uromodulin combined with optimized growth conditions for E. coli. The study does not immediately support the notion that established UTIs can be eliminated by increased water intake.