Clinical and Ultrasound Thyroid Nodule Characteristics and Their Association with Cytological and Histopathological Outcomes: A Retrospective Multicenter Study in High-Resolution Thyroid Nodule Clinics.
María Molina VegaCarlos Antonio Rodríguez-PérezAna Isabel Álvarez-ManchaGloria Baena-NietoMaría RiestraVictoria AlcázarAna Reyes Romero-LluchJuan C GalofréJosé Carlos Fernández-GarcíaPublished in: Journal of clinical medicine (2019)
In this large multicenter study, we found that the presence of a solid component and irregular margins are factors independently related to malignancy in thyroid nodules. Since nodule size ≥40 mm was associated with the lowest odds of malignancy, this cut-off should not be a factor leading to indicate thyroid surgery. HR-TNCs were associated with a low rate of nondiagnostic FNA.