Successful ovarian tissue cryopreservation with transvaginal natural orifice transluminal endoscopic surgery: A case report.
Tetsuro HanadaAkimasa TakahashiYuji TanakaAkie TakebayashiYoshie MatsudaMakiko KasaharaShunichiro TsujiTakashi MurakamiPublished in: Women's health (London, England) (2024)
Chemotherapy and radiation therapy can cause gonadal dysfunction in women of reproductive age. Ovarian tissue cryopreservation is performed to restore fertility by allowing transplantation of the patient's frozen-thawed ovarian tissue or through future in vitro maturation and in vitro fertilization of frozen-thawed oocytes. Herein, we describe our initial experience with vaginal natural orifice transluminal endoscopic surgery for ovarian tissue preservation in a young woman with malignant tumor. A 23-year-old woman with anaplastic lymphoma kinase-positive malignant lymphoma was scheduled for hematopoietic stem cell transplantation after experiencing relapse following R-cyclophosphamide, doxorubicin, vincristine, and prednisolone therapy. Ovarian tissue cryopreservation was selected as only MII2 oocytes were collected. Vaginal natural orifice transluminal endoscopic surgery was performed to excise the left ovary. Ovarian tissues were frozen using the vitrification method. The operative time was 37 min, and blood loss was minimal. Pathological examination revealed no metastatic findings of malignant lymphoma and no thermal damage to the ovarian tissue due to bipolar disorder. The patient was discharged on the first day postoperatively, and her postoperative course was uneventful. The vaginal natural orifice transluminal endoscopic surgery technique can provide a safe and effective alternative to laparoscopy or laparotomy for the cryopreservation of ovarian tissue in young patients with cancer. We believe this method has potential application in sexually mature female cancer survivors.
Keyphrases
- minimally invasive
- radiation therapy
- bipolar disorder
- coronary artery bypass
- ultrasound guided
- diffuse large b cell lymphoma
- case report
- gene expression
- small cell lung cancer
- squamous cell carcinoma
- coronary artery disease
- patients undergoing
- stem cells
- low dose
- acute myeloid leukemia
- drug delivery
- surgical site infection
- major depressive disorder
- young adults
- mesenchymal stem cells
- bone marrow
- current status
- radiation induced
- free survival