Hypermethylation of Proopiomelanocortin and Period 2 Genes in Blood Are Associated with Greater Subjective and Behavioral Motivation for Alcohol in Humans.

Omkaram GangisettyRajita SinhaDipak K Sarkar

Published in: Alcoholism, clinical and experimental research (2018)

These data establish significant association between binge or heavy levels of alcohol drinking and elevated levels of methylation and reduced levels of expression of POMC and PER2 genes. Furthermore, elevated methylation of POMC and PER2 genes is associated with greater subjective and behavioral motivation for alcohol.

Keyphrases

genome wide
alcohol consumption
dna methylation
genome wide identification
bioinformatics analysis
genome wide analysis
electronic health record
transcription factor
artificial intelligence
data analysis