Phospholipase A2 receptor 1 promotes lung cell senescence and emphysema in obstructive lung disease.

Delphine BeaulieuAya AttweMarielle BreauLarissa LipskaiaElisabeth MarcosEmmanuelle BornJin HuangShariq AbidGeneviève DerumeauxAmal HoussainiBernard MaitreMarine LefevreNora VienneyPhilippe BertolinoSara JaberHiba NoureddineDelphine GoehrigDavid VindrieuxDavid BernardSerge Adnot

Published in: The European respiratory journal (2021)

Our data support a major role for PLA2R1 activation in driving lung cell senescence and lung alterations in COPD. Targeting JAK1/2 may represent a promising therapeutic approach for COPD.

Keyphrases

chronic obstructive pulmonary disease
lung function
single cell
cell therapy
dna damage
endothelial cells
stress induced
electronic health record
stem cells
cancer therapy
big data
mesenchymal stem cells
air pollution
bone marrow