Novel Antimicrobial Indolepyrazines A and B from the Marine-Associated Acinetobacter sp. ZZ1275.
Komal AnjumSidra KaleemWenwen YiGuowan ZhengXiaoyuan LianZhizhen ZhangPublished in: Marine drugs (2019)
Two new alkaloids indolepyrazines A (1) and B (2) were isolated from the marine-derived Acinetobacter sp. ZZ1275. Their structures were elucidated through extensive nuclear magnetic resonance (NMR) spectroscopic analyses, high resolution electrospray ionization mass spectroscopy (HRESIMS) data, and electronic circular dichroism (ECD) calculation. Indolepyrazine A represents the first example of alkaloids with an indole-pyrazine-oxindole skeleton. Both 1 and 2 showed antimicrobial activities against methicillin-resistant Staphylococcus aureus, Escherichia coli, and Candida albicans with minimum inhibitory concentration (MIC) values of 12 μg/mL, 8⁻10 μg/mL, and 12⁻14 μg/mL, respectively.
Keyphrases
- high resolution
- methicillin resistant staphylococcus aureus
- staphylococcus aureus
- candida albicans
- biofilm formation
- magnetic resonance
- escherichia coli
- acinetobacter baumannii
- mass spectrometry
- molecular docking
- pseudomonas aeruginosa
- electronic health record
- contrast enhanced
- tandem mass spectrometry
- drug resistant
- computed tomography
- monte carlo
- klebsiella pneumoniae
- machine learning
- data analysis
- artificial intelligence