Association of Tumor-Infiltrating Lymphocytes with Homologous Recombination Deficiency and BRCA1/2 Status in Patients with Early Triple-Negative Breast Cancer: A Pooled Analysis.
Melinda L TelliCharles ChuSunil S BadveShaveta VinayakDaniel P SilverSteven J IsakoffVirginia G KaklamaniWilliam GradisharVered StearnsRoisin M ConnollyJames M FordJoshua J GruberSylvia AdamsJudy E GarberNadine TungChris NeffRyan BernhiselKirsten M TimmsAndrea L RichardsonPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2019)
In patients with TNBC treated with neoadjuvant platinum-based therapy, TIL density was not significantly associated with either tumor BRCA1/2 mutation status or HRD status. In this pooled analysis, HRD and sTIL density were independently associated with treatment response, with HRD status being the strongest predictor.