Effect of CYB2B6 (c.516G>T), CYP2C9 (c.1075A>C) and UGT1A9 (c.98T>C) polymorphisms on propofol pharmacokinetics in patients submitted to colonoscopy: a cohort study.

Mara Aparecida Maricato PomaHoward Lopes Ribeiro JuniorEugênio Araújo CostaCarlos Roberto Koscky PaierLaís Lacerda BrasilLuína Benevides LimaLivia Maria Soares NobreTayales Tavares LeiteRoberto César Pereira Lima-JúniorAna Rosa Pinto QuiduteMaria Elisabete Amaral de MoraesManoel Odorico de Moraes Filho

Published in: Postgraduate medical journal (2023)

We concluded that the rs1057910 and rs3745274 polymorphisms affect the metabolism of propofol in patients exclusively submitted to this drug. Thus, the knowledge of the polymorphic genotypes of the CYPP2C9 and CYB2B6 genes may be predictive of different metabolising phenotypes, suggesting expected behaviours of BIS parameter in the anaesthetic procedure, which contributes to safer monitoring by anaesthesiologists during the clinical intervention.

Keyphrases

end stage renal disease
newly diagnosed
ejection fraction
chronic kidney disease
peritoneal dialysis
healthcare
emergency department
gene expression
minimally invasive