Safeguarding Neuronal Integrity: Unveiling Possible Role of NFκB in the Neuroprotective Efficacy of Andrographolide Contrary to Aluminium Chloride-induced Neurotoxicity and Associated Spatial Memory Impairments in Rats.

Abhitinder Kumar Mohit Agrawal Yogesh Murti Simran Behl Shivendra Kumar Hema Chaudhary Kuldeep Singh Sunam Saha Sameer Rastogi

Published in: Central nervous system agents in medicinal chemistry (2024)

These findings collectively suggest that andrographolide holds the potential to counteract memory impairment instigated by aluminum toxicity, accomplished through the modulation of NFκB activity and the amelioration of the adverse consequences of AlCl3 exposure.

Keyphrases

signaling pathway
oxidative stress
lps induced
working memory
diabetic rats
pi k akt
cerebral ischemia
nuclear factor
high glucose
emergency department
subarachnoid hemorrhage
drug induced
cell proliferation
endothelial cells
human health
blood brain barrier
brain injury