Comprehensive tumor profiling reveals unique molecular differences between peritoneal metastases and primary colorectal adenocarcinoma.
Matthew K SteinForrest W WilliardJoanne XiuMiriam W TsaoMichael G MartinBenjamin W DeschnerPaxton V DicksonEvan S GlazerDanny YakoubDavid ShibataAxel F GrotheyPhilip A PhilipJimmy J HwangAnthony F ShieldsJohn L MarshallW Michael KornHeinz-Josef LenzJeremiah L DenevePublished in: Journal of surgical oncology (2020)
PM have similar rates of KRAS mutation with increased PATHs in GNAS (mucinous) and BRAF (nonmucinous) compared to pCRC. No differences in MSI or TMB were identified between PM and pCRC tumors. These findings inform future study into the molecular profile of PM.