Resolvin D2 Attenuates Cardiovascular Damage in Angiotensin II-Induced Hypertension.
Lucía Serrano Díaz Del CampoAna B García-RedondoCristina RodriguezCarlos ZaragozaSantiago Duro-SánchezFrancesco PalmasAngela de Benito-BuenoPaula G SocuellamosDiego A PerazaRaquel Rodrigues-DíezCarmen ValenzuelaJesmond DalliMercedes SalaicesAna M BrionesPublished in: Hypertension (Dallas, Tex. : 1979) (2022)
There is a disbalance between proinflammatory and resolution mediators in hypertension. RvD2 protects cardiovascular function and structure when administered before and after the development of hypertension by modulating vascular factors, fibrosis and inflammation. Activating resolution mechanisms by treatment with RvD2 may represent a novel therapeutic strategy for the treatment of hypertensive cardiovascular disease.