Effect of Tolvaptan in Patients with Chronic Kidney Disease Stage G5, and Impact of Concomitant Use of Thiazide Diuretics: A Retrospective Cohort Study.

Kiyotaka UchiyamaDaiki KojimaEriko Yoshida HamaTomoki NagasakaTakashin NakayamaRina TakahashiTakaya TajimaKohkichi MorimotoNaoki WashidaHiroshi Itoh

Published in: Drugs - real world outcomes (2022)

Tolvaptan exhibited significant diuretic effects in patients with CHF, including those with severe renal dysfunction, which were diminished with concomitant thiazide diuretic use.

Keyphrases

acute heart failure
heart failure
polycystic kidney disease
oxidative stress
early onset