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A Synopsis Clonal Hematopoiesis of Indeterminate Potential in Hematology.

Maroun Bou ZerdanLewis NasrLudovic SabaPaul MeouchyNadine SafiSabine AllamJenish BhandariChakra P. Chaulagain
Published in: Cancers (2022)
Clonal hematopoiesis of indeterminate potential can be defined as genetic mutations that correlate in hematologic neoplasia such as myelodysplastic syndrome. Patients with cytopenia increasingly undergo molecular genetic tests of peripheral blood or bone marrow for diagnostic purposes. Recently, a new entity has been demarcated to lessen the risk of incorrect diagnoses of hematologic malignancies. This new entity is a potential precursor of myeloid diseases, analogous to monoclonal gammopathy of undetermined significance as a potential precursor of multiple myeloma.
Keyphrases
  • bone marrow
  • peripheral blood
  • multiple myeloma
  • mesenchymal stem cells
  • acute myeloid leukemia
  • high grade
  • single molecule