Changes in contractile protein expression are linked to ventricular stiffness in infants with pulmonary hypertension or right ventricular hypertrophy due to congenital heart disease.
Andrew R BondDominga IacobazziSafa Abdul-GhaniMohammed GhorbelKate HeesomMariangela WilsonChristopher GillettSarah J GeorgeMassimo CaputoSaadeh SuleimanRobert Michael TullohPublished in: Open heart (2018)
This is the first demonstration that those with an RV, which is stiff and hypertensive in TOF, have a range of altered proteins, often in calcium signalling pathways. Information about these alterations might guide treatment options both in terms of individualised therapy or inotropic support for the Right ventricle when hypertensive due to pulmoanry hypertension or congenital heart disease.
Keyphrases
- congenital heart disease
- blood pressure
- pulmonary hypertension
- mycobacterium tuberculosis
- pulmonary artery
- mass spectrometry
- heart failure
- ms ms
- pulmonary arterial hypertension
- skeletal muscle
- left ventricular
- health information
- smooth muscle
- healthcare
- stem cells
- atrial fibrillation
- cell therapy
- arterial hypertension