Pathological and immunohistochemical aspects of acute megakaryoblastic leukaemia in a cat - Short communication.
Franciéli Adriane MolossiLuan Cleber HenkerBianca Santana De CeccoMarcele Bettim BandinelliRochana RodriguesLuciana SonneDavid DriemeierSaulo Petinatti PavariniPublished in: Acta veterinaria Hungarica (2021)
An adult, mixed-breed, feline leukaemia virus (FeLV-) positive female cat was presented with mucosal jaundice and a history of anorexia and constipation for three days. Physical examination revealed splenomegaly, cachexia, and dehydration. Humane euthanasia was conducted, followed by postmortem examination. Grossly, the cat was icteric, and presented hepatomegaly with multifocal white spots and splenomegaly. Histologically, the bone marrow was nearly completely replaced by a proliferation of megakaryocytes and megakaryoblasts, and there was a proliferation of fibrous connective tissue. Similar neoplastic proliferation was observed infiltrating the liver, lymph nodes, spleen, kidney, skeletal muscle, and lungs. Immunohistochemistry was performed for von Willebrand Factor (VWF), CD79α, CD3, feline immunodeficiency virus, FeLV, and CD61. Marked cytoplasmic labelling was observed in the neoplastic cells for FeLV, VWF and CD61, corroborating the diagnosis of acute megakaryoblastic leukaemia.
Keyphrases
- signaling pathway
- liver failure
- skeletal muscle
- bone marrow
- lymph node
- induced apoptosis
- respiratory failure
- drug induced
- mental health
- aortic dissection
- mesenchymal stem cells
- insulin resistance
- physical activity
- nk cells
- type diabetes
- intensive care unit
- single cell
- cell proliferation
- endoplasmic reticulum stress
- cell death
- pi k akt