Volume incompliance and transfusion are essential for transfusion-associated circulatory overload: a novel animal model.
Robert B KlandermanJoachim J BosboomAdrie A W MaasJoris J T H RoelofsDirk de KorteRobin van BruggenJaap D van BuulCoert J ZuurbierDenise P VeeloMarkus W HollmannMargreeth B VroomNicole P JuffermansBart F GeertsAlexander P J VlaarPublished in: Transfusion (2019)
To our knowledge, this is the first animal model for TACO, showing that a combination of volume incompliance and transfusion is essential for development of circulatory overload. This model allows for further testing of mechanistic factors as well as therapeutic approaches.