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Developmental and neurodegenerative damage in Friedreich's ataxia.

Thiago Junqueira Ribeiro de RezendeA R M MartinezI FaberK A Girotto TakazakiM P MartinsF D de LimaI Lopes-CendesF CendesM C França
Published in: European journal of neurology (2018)
Structural damage in FRDA begins in the spinal cord and inferior cerebellar peduncle as well as the red nucleus, and progresses to cerebral areas in adulthood. These results shed some light on the early stages of FRDA and highlight potential neuroimaging markers for therapeutic trials.
Keyphrases
  • spinal cord
  • oxidative stress
  • spinal cord injury
  • subarachnoid hemorrhage
  • depressive symptoms
  • neuropathic pain
  • early onset
  • brain injury
  • blood brain barrier
  • cerebral blood flow