Developmental and neurodegenerative damage in Friedreich's ataxia.

Thiago Junqueira Ribeiro de RezendeA R M MartinezI FaberK A Girotto TakazakiM P MartinsF D de LimaI Lopes-CendesF CendesM C França

Published in: European journal of neurology (2018)

Structural damage in FRDA begins in the spinal cord and inferior cerebellar peduncle as well as the red nucleus, and progresses to cerebral areas in adulthood. These results shed some light on the early stages of FRDA and highlight potential neuroimaging markers for therapeutic trials.

Keyphrases

spinal cord
oxidative stress
spinal cord injury
subarachnoid hemorrhage
depressive symptoms
neuropathic pain
early onset
brain injury
blood brain barrier
cerebral blood flow