Exosomal miR-6733-5p mediates cross-talk between glioblastoma stem cells and macrophages and promotes glioblastoma multiform progression synergistically.
Shilu HuangLiang LiuZhipeng XuXinglei LiuAnyi WuXiaopei ZhangZengyang LiSuwen LiYongdong LiJiaqi YuanShan ChengHaoran LiJun DongPublished in: CNS neuroscience & therapeutics (2023)
GSCs secrete miR-6733-5p-rich exosomes to induce M2-like polarization of macrophages, as well as enhance GSCs stemness and promote malignant behaviors of GBM through IGF2BP3 activated AKT pathway. Targeting GSCs exosomal miR-6733-5p may provide a potential new strategy against GBM.