Role of cyclooxygenase pathways in bowel fibrotic remodelling in a murine model of experimental colitis.

Rocchina ColucciMatteo FornaiLuca AntonioliCristina SegnaniChiara IppolitoCarolina PellegriniAnna NericcioMaria Grazia ZizzoRosa SerioCorrado BlandizziNunzia Bernardini

Published in: The Journal of pharmacy and pharmacology (2022)

Colonic fibrosis is associated with altered bowel motility and induction of profibrotic factors driven by TGF-β signalling. COX-1 and COX-2 inhibition counteracts this fibrotic remodelling by the modulation of TGF-β/SMAD signalling, mainly via SMAD6 induction and reduction in SMAD2 phosphorylation.

Keyphrases

transforming growth factor
epithelial mesenchymal transition
systemic sclerosis
idiopathic pulmonary fibrosis
ulcerative colitis
signaling pathway
escherichia coli
staphylococcus aureus
nitric oxide synthase
liver fibrosis