Protein and transcriptional biomarker profiling may inform treatment strategies in lower respiratory tract infections by indicating bacterial-viral differentiation.
Dhanasekaran SivakumaranSynne JenumDagfinn Lunde MarkussenSondre SerigstadAashish SrivastavaChristina Skår SaghaugElling UlvestadSiri Tandberg KnoopHarleen M S GrewalPublished in: Microbiology spectrum (2024)
Accurate differentiation between bacterial and viral lower respiratory tract infections (LRTIs) is vital for effective patient care and resource allocation. This study investigated specific protein signatures and gene expression patterns in plasma and blood samples from LRTI patients that distinguished bacterial and viral infections. The identified signatures can inform the design of point-of-care tests that can aid healthcare providers in making informed decisions about antibiotic prescriptions in order to reduce unnecessary use, thereby contributing to reduced side effects and antibiotic resistance. Furthermore, the potential for faster and more accurate diagnoses for improved patient management in acute LRTIs is compelling.
Keyphrases
- respiratory tract
- gene expression
- sars cov
- healthcare
- end stage renal disease
- ejection fraction
- newly diagnosed
- genome wide
- chronic kidney disease
- high resolution
- peritoneal dialysis
- liver failure
- dna methylation
- prognostic factors
- protein protein
- amino acid
- case report
- single cell
- respiratory failure
- intensive care unit
- risk assessment
- drug induced
- small molecule
- acute respiratory distress syndrome
- heat shock
- aortic dissection
- health information
- extracorporeal membrane oxygenation
- heat stress