LncRNA LOC105378097 inhibits cardiac mitophagy in natural ageing mice.

Xin LiuXue BaiHeng LiuYang HongHao CuiLei WangWanqing XuLimin ZhaoXiaohan LiHuimin LiXia LiHui ChenZiyu MengHan LouHenghui XuYuan LinZhimin DuPhilipp KopylovBaofeng Yang Yong Zhang

Published in: Clinical and translational medicine (2022)

The present study for the first time demonstrates a heart-enriched lncRNA, SMAL, that inhibits the mitophagy of cardiomyocytes via the downregulation of Parkin protein, which further contributes to heart ageing and cardiac dysfunction in natural ageing mice.

Keyphrases

high fat diet induced
heart failure
left ventricular
long non coding rna
atrial fibrillation
cell proliferation
oxidative stress
nlrp inflammasome
signaling pathway
insulin resistance
binding protein
skeletal muscle