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Impact of 30-day prescribed opioid dose trajectory on fatal overdose risk: A population-based, statewide cohort study.

Stephen G HenryShao-You FangAndrew J CrawfordGaren J WintemuteIraklis Erik TseregounisJames J GasperAaron ShevAbigail R CartusBrandon D L MarshallDaniel J TancrediMagdalena CerdáSusan L Stewart
Published in: Journal of general internal medicine (2023)
Large (≥2 categories) 30-day dose increases and decreases were both associated with increased risk of fatal opioid overdose, particularly for patients taking ≥90 MME whose opioids were abruptly stopped. Results align with 2022 CDC guidelines that urge caution when reducing opioid doses for patients taking long-term opioid for chronic pain.
Keyphrases
  • chronic pain
  • pain management
  • end stage renal disease
  • ejection fraction
  • chronic kidney disease
  • newly diagnosed
  • prognostic factors
  • cell proliferation
  • cell cycle
  • clinical practice