TRPV1 controls innate immunity during Citrobacter rodentium enteric infection.
Michael CreminEmmy TayValerie T RamirezKaitlin MurrayRene K NicholsIngrid Brust-MascherColin ReardonPublished in: bioRxiv : the preprint server for biology (2023)
Neuroimmune communications are vital in regulating the immune response to invading pathogens. Here, we show that during a gastrointestinal infection, pain-sensing neuronal fibers can modulate the immune response to recruit phagocytic neutrophils via upregulation of cell adhesion molecules on local blood endothelial cells. This research elucidates a novel impact of the pain-sensing ion channel, TRPV1, on host-pathogen interactions in the gastrointestinal tract as well as a potential methodology for modulating the immune response during enteric infections.
Keyphrases
- neuropathic pain
- cell adhesion
- chronic pain
- immune response
- endothelial cells
- pain management
- signaling pathway
- spinal cord
- spinal cord injury
- gram negative
- cell proliferation
- risk assessment
- postoperative pain
- human health
- toll like receptor
- high glucose
- inflammatory response
- multidrug resistant
- brain injury
- cerebral ischemia