Myocardial susceptibility to ischaemia/reperfusion in obesity: a re-evaluation of the effects of age.
I WebsterR SalieE MaraisW-J FanG MaarmanB HuisamenAmanda LochnerPublished in: BMC physiology (2017)
The data showed that middle-age and obesity had no effect on baseline myocardial function and did not increase susceptibility to I/R damage upon exposure to regional ischaemia. On the contrary, obesity reduced I/R damage in young rats. Preconditioned aging hearts showed a decreased infarct size, but a reduction in functional recovery.
Keyphrases
- insulin resistance
- metabolic syndrome
- weight loss
- high fat diet induced
- type diabetes
- weight gain
- left ventricular
- acute myocardial infarction
- oxidative stress
- adipose tissue
- physical activity
- machine learning
- deep learning
- brain injury
- coronary artery disease
- data analysis
- cerebral ischemia
- big data
- acute coronary syndrome
- subarachnoid hemorrhage