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Unfolded protein response pathway in leishmaniasis: A review.

Nimesha Madhushani EdirisingheNuwani Harshamali ManamperiVishmi Samudika WanasingheNadira Darshani Karunaweera
Published in: Parasite immunology (2023)
Alteration in the physiological state of the endoplasmic reticulum (ER) leads to the specific response known as unfolded protein response (UPR) or ER stress response. The UPR is driven by three sensor proteins, namely: Inositol-Requiring Enzyme 1, Protein Kinase RNA-like ER kinase and Activating Transcription Factor 6 to restore ER homeostasis. Pathogenic infection can initiate UPR activation; some pathogens can subvert the UPR to promote their survival and replication. Many intracellular pathogens, including Leishmania, can interact and hijack ER for their survival and replication, triggering ER stress and subsequently ER stress response. This review aims to provide a comprehensive overview of the ER stress response in infections with the Leishmania species.
Keyphrases
  • endoplasmic reticulum
  • estrogen receptor
  • transcription factor
  • breast cancer cells
  • protein kinase
  • signaling pathway
  • small molecule
  • antimicrobial resistance
  • multidrug resistant
  • reactive oxygen species