A metal-free fluorescence turn-on molecular probe for detection of nucleoside triphosphates.
Debabrata MaityMao LiMartin EhlersAlba GiganteCarsten SchmuckPublished in: Chemical communications (Cambridge, England) (2017)
We report a fluorescence probe 1, which contains a naphthalimide fluorophore with two symmetric peptidic arms equipped with a tailor-made anion-binding motif, the guanidiniocarbonyl pyrrole moiety, for the detection of nucleoside triphosphates. Upon binding to nucleoside triphosphates, especially ATP, 1 shows significant turn-on fluorescence response. Probe 1 can also be applied for the imaging of ATP in cells.
Keyphrases
- living cells
- fluorescent probe
- single molecule
- energy transfer
- loop mediated isothermal amplification
- quantum dots
- induced apoptosis
- sensitive detection
- high resolution
- real time pcr
- label free
- cell cycle arrest
- ionic liquid
- oxidative stress
- cell death
- signaling pathway
- transcription factor
- cell proliferation
- binding protein
- photodynamic therapy