Impact of Variant Reclassification in Cancer Predisposition Genes on Clinical Care.
Jian Bang ChiangTze Hao ChiaJeanette YuenTarryn ShawShao-Tzu LiNur Diana Binte IshakEe Ling ChewSiao Ting ChongSock Hoai ChanJoanne NgeowPublished in: JCO precision oncology (2022)
We propose a clinical guideline to standardize management of patients reported to have variants of uncertain significance. Management should be based on the patient's personal history, family history, and variant interpretation. For clinically relevant or suspicious variants of uncertain significance, follow-up is recommended every 2 years, as actionable reclassifications may happen during this period.