Silencing Smad7 potentiates BMP2-induced chondrogenic differentiation and inhibits endochondral ossification in human synovial-derived mesenchymal stromal cells.

Pengcheng XiaoZhenglin ZhuChengcheng DuYongsheng ZengJunyi LiaoQiang ChengHong ChenChen ZhaoWei Huang

Published in: Stem cell research & therapy (2021)

This study suggests that the application of hSMSCs, cell scaffolds, and silencing Smad7 can potentiate BMP2-induced chondrogenic differentiation and inhibit endochondral ossification. Thus, inhibiting the expression of Smad7 in BMP2-induced hSMSC differentiation may be a new strategy for cartilage tissue-engineering.

Keyphrases

mesenchymal stem cells
tissue engineering
high glucose
diabetic rats
epithelial mesenchymal transition
endothelial cells
transforming growth factor
drug induced
bone marrow
signaling pathway
oxidative stress
single cell
stem cells
extracellular matrix