Mitochondrial transfer from Adipose stem cells to breast cancer cells drives multi-drug resistance.

Vitale Del VecchioAyesha RehmanSameer Kumar PandaMartina TorsielloMartina MariglianoMaria Maddalena NicolettiGiuseppe Andrea FerraroVincenzo De FalcoRosamaria LappanoEva LietoFrancesca PagliucaCarlo CaputoMarcella La NoceGianpaolo PapaccioVirginia TirinoNirmal RobinsonVincenzo DesiderioFederica Papaccio

Published in: Journal of experimental & clinical cancer research : CR (2024)

We provide a proof-of-concept of the occurrence of Mitochondrial Transfer (MT) from Adipose Stem Cells (ASCs) to BC models. Blocking MT from ASCs to BCCs could be a new effective therapeutic strategy for BC treatment.

Keyphrases

stem cells
breast cancer cells
oxidative stress
adipose tissue
insulin resistance
risk assessment
cell therapy
metabolic syndrome
replacement therapy
smoking cessation