Characterizing heart failure with preserved and reduced ejection fraction: An imaging and plasma biomarker approach.
Prathap KanagalaJayanth R ArnoldAnvesha SinghDaniel C S ChanAdrian S H ChengJamal N KhanGaurav S GulsinJing YangLei ZhaoPankaj GuptaIain B SquireLeong L NgGerry P McCannPublished in: PloS one (2020)
HFpEF is a distinct pathophysiological entity compared to age- and sex-matched HFrEF and controls. HFpEF and HFrEF are associated with similar adverse outcomes. Inflammation is common in both HF phenotypes but cardiomyocyte stretch/stress is greater in HFrEF.