Solid optical tissue phantom tools based on upconverting nanoparticles for biomedical applications.

Gokhan DumlupinarSanathana Konugolu Venkata Sekar Claudia Nunzia GuadagnoJean S MatiasPranav LankaChris K W KhoStefan Andersson-Engels

Published in: Journal of biomedical optics (2023)

A first-of-its-kind UCNP-based solid phantom recipe was developed, and four types of UCNP phantom tools to explore biophotonics applications were presented. The UCNP phantoms exhibited a linear behavior with dosage and were stable over time. An example case showed the potential use of the phantom for deep tissue imaging applications. With recent advance in the use of UCNPs for biophotonics, we believe our recipe and tools will play a pivotal role in the growth of the UCNPs for biophotonics applications.

Keyphrases

image quality
dual energy
high resolution
monte carlo
computed tomography
magnetic resonance imaging
risk assessment
high speed
human health
mass spectrometry