Single-Cell Profiling Reveals Immune Aberrations in Progressive Idiopathic Pulmonary Fibrosis.

Avraham UntermanAmy Y ZhaoNir NeumarkJonas Christian Schupp Farida AhangariCarlos CosmePrapti SharmaJasper FlintYan SteinChangwan RyuGenta IshikawaTomokazu S SumidaJose L GomezJose D Herazo-MayaCharles S Dela CruzErica L HerzogNaftali Kaminski

Published in: American journal of respiratory and critical care medicine (2024)

The single-cell atlas of the peripheral immune system in IPF, reveals an outcome-predictive increase in classical monocytes and Tregs, as well as evidence for a lung-blood immune recruitment axis involving CCL7 (for classical monocytes) and CCL18/CCL22 (for Tregs).

Keyphrases

single cell
idiopathic pulmonary fibrosis
rna seq
liver fibrosis
liver injury
high throughput
interstitial lung disease
drug induced
dendritic cells
peripheral blood
multiple sclerosis
copy number
gene expression
dna methylation